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Codeine converts into its Lively metabolite morphine by means of the hepatic CYP2D6 isoenzyme, which click here displays genetic polymorphisms. For that reason, clinicians contraindicate codeine in individuals recognized as “ultrafast CYP2D6 metabolizers.”
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In the same way, drugs that inhibit liver enzymes can elevate blood amounts of codeine, growing the risk of adverse results.